Health Mania

Inflammation of the brain associated with sclerosis may be causing depression, according to research.  Patients with multiple sclerosis  have seen higher rates of depression  - compared to the general population.  Abnormal immune response, one of the characteristic symptoms of multiple sclerosis, is also linked to depression.  Researchers believe this may be a shared pathological mechanism, which helps explain the link between multiple sclerosis and rates of depression. The results add evidence to support that inflammation of the hippocampus alters its function and contributes to depressive symptoms.  Hippocampus is involved in the maintenance of depression and the pathology of multiple sclerosis. The researchers combined two complementary brain imaging techniques to study the relationship between hippocampal immune response, functional connections, and depressive symptoms in 13 multiple sclerosis patients and 22 healthy controls.  Imaging techniques i...

Research from the University of Toronto has taken us a step closer to understanding the cause of multiple sclerosis (MS).  Multiple sclerosis is an autoimmune disease in which the immune system attacks and damages the protective covering of nerve cells in the brain and spinal cord.  The immune system normally works to protect us from viruses or pathogens, but in the case of MS, we are not protected so the condition is caused by a deterioration of nerves. Previous research has found that specific white blood cells, called lymphocytes, accumulate in tertiary lymphoid tissues (TLTs) in the brain of people with MS.  Although the function of TLTs has been discovered, it is not yet clear how they form and remain in the brain. The researchers found that TLTs were created by the presence of stromal cells, which produce complex fibers.  These cells form nets in which T accumulates 17 cells (T cell type). “While autoimmune disorders are an important part of the body's ability ...

Multiple sclerosis (MS) may be triggered by the death of myelin-producing brain cells (oligodendrocytes), leading to an autoimmune response against myelin.  The findings come from researchers at the University of Chicago and Northwestern Medicine who developed novel mouse models to conduct their studies.  The researchers found that the death of oligodendrocytes triggers an autoimmune response against myelin, triggering multiple sclerosis-like symptoms in mice. On the other hand, the researchers found that the reaction can be prevented by using specially developed nanoparticles even after brain cells are lost.  These nanoparticles are now being developed in clinical trials with the potential for future treatments for humans. Co-senior author Brian Popko said, “Although this was a study in mice, we first demonstrated one mechanism that could induce MS - the death of the cells responsible for generating myelin. cause autoimmune activation response against.  Protecting t...